为了了解玻璃是如何影响Katritzky反应速率的，作者在塑料小瓶中进

In order to understand how glass affects the Katritzky reaction rate, the author carried out the reaction in a plastic vial and added additional acid or base. It was found that the addition of 1 equivalent of acetic acid had no significant effect on the reaction kinetics. Even if a plastic container was used for 3 h under acidic conditions, the yield was very low (< 1%), and the abundance of intermediates was also extremely low (< 0.1% ). In contrast, the reaction kinetics under the conditions of 0.01 equivalent, 0.1 equivalent and 1 equivalent of triethylamine showed a linear relationship similar to that of glass beads. These results indicate that the Katritzky reaction requires base deprotonation to form intermediates, while the silanol groups on the glass surface exist in the form of silanol anions in organic solvents, which can act as Brønsted-Lowry bases to participate in deprotonation. It further explained the reason for the influence of glass on the Katritzky reaction rate.

To understand how glass affects the rate of Katritzky reactions, the authors responded in plastic vials with additional acids or alkalis. It was found that the addition of 1 equivalent acetic acid had no significant effect on reaction dynamics, even if the use of plastic container reaction 3 h under acidic conditions, the yield was very low (< 1%), and the abundance of intermediates was very low (< 0.1%). In contrast, reaction dynamics under 0.01 equivalent, 0.1 equivalent, and 1 equivalent triethylamine showed a linear relationship similar to glass microbeads. These results show that the Katritzky reaction requires the deprotonization of alkalis to form intermediates, while the silicone alcohol group on the glass surface is present in the form of silicone anions in the organic solvent, which can act as a participation in deprotonization of the Brensted-Lowry alkali, further explaining the effect of glass on the rate of Katritzky reaction.

In order to understand how glass affects the katritzky reaction rate, the reaction was carried out in plastic vials with additional acids or bases added. The results showed that the addition of 1 equivalent acetic acid had no obvious effect on the reaction kinetics, and the yield was very low (< 1%) and the abundance of intermediates was very low (< 0.1%) even when the reaction was carried out in a plastic container under acidic conditions for 3 h. In contrast, the reaction kinetics at 0.01 equivalent, 0.1 equivalent and 1 equivalent triethylamine showed a similar linear relationship with glass beads. These results indicate that the katritzky reaction needs deprotonation of bases to form intermediates, and the silanol group on the surface of glass exists in the form of silanol anion in organic solvents, which can act as br ú nsted Lowry base to participate in deprotonation, further explaining the reason why glass affects the rate of katritzky reaction.<br>