Immunocompromised condition include

Immunocompromised condition included hematologic malignancy, prior bone marrow transplant, or received immunosuppressive therapy, such as cancer chemotherapy, anti-rejection medications for transplantation, or long term( 2 weeks)use of systemic steroids.Neutropenia was defined as 500 neutrophils/mm3.Although a patient may have had 2 or more different types of transplantations, the same patient was only counted once in the prior transplantations category.Chronic renal insufficiency was defined as moderate to severe renal disease.A patient may have had more than one comorbid condition/disease.The patient was counted once for each comorbid condition/disease.Patients with AP and cUTI in this table were summarized from Post-text Tables 2.2.2 and 2.2.4.Ineffective empiric treatment was defined as treatment with empiric antibiotics to which the isolates were not susceptible.Shock or profound hypotension defined as systolic blood pressure 90 mmHg or a decrease of 40 mmHg from baseline(if known)that is not responsive to fluid challenge; hypothermia(core temperature 35.6 ℃ or 96.1℉); or disseminated intravascular coagulation as evidenced by prothrombin time or partial thromboplastin time 2 x the upper limit of normal or platelets 50% of the lower limit of normal.AP=acute pyelonephritis; APACHE II=Acute Physiology and Chronic Health Evaluation II; CRE=carbapenem-resistant Enterobacteriaceae; cUTI=complicated urinary tract infection; HABP=hospital-acquired bacterial pneumonia;IQR=interquartile range; IV=intravenous; NA=not applicable; SD=standard deviation; VABP=ventilator-associated bacterial pneumonia.Sources:Post-text Tables 2.1.1, 2.2.1.1, 2.2.2, 2.2.4, 2.2.5, 2.3.1, 2.3.2(post-hoc), 2.4.1, 2.5.2, 2.6.1, 2.8.1, 2.9.1.1, and 2.10.1; and Post-text Data Listings 2.2.1.1 and 2.2.1.2Patient Characteristics - All Cases(Continued)Comorbidities(Continued)Any non-metastatic solid tumorConcurrent Bacteremia[8]Ineffective empiric treatment[9]- n(%)Presentation with shock[10]APACHE II score - mean(SD)Not applicable for this retrospective chart review study.Table 2 summarizes baseline specimen culture results by sites of collection for All Cases.Of the 257 cases of CRE infections, 146(56.8%)baseline specimens were collected from blood, 72(28.0%)from urine, 39(15.2%)from a pulmonary tract, and 1(0.4%)from another site.A CRE was isolated from a respiratory culture from all 21(100%)HABP cases and the majority(18[90%])of VABP cases; in 2(10.0%)VABP cases, the index CRE was collected from a blood sample.In the majority(72[94.7%])of cUTI/AP cases, the index CRE was collected on a urine culture; in 5(6.6%)cUTI/AP cases, the index CRE was collected from a blood culture.In almost all cases of bacteremia(139[99.3%]), the index CRE was collected from a blood sample; in the 1(0.7%)remaining case of bacteremia, the index CRE was collected from another source.Summary of Baseline Specimen - All CasesSite of Collection - n(%)AP=acute pyelonephritis; cUTI=complicated urinary tract infection; HABP=hospital-acquired bacterial pneumonia;Table 3 summarizes baseline specimen culture by type of gram-negative pathogen present for All Cases.All 257 cases of infection had gram-negative pathogens present at baseline.Some cases of infection had more than 1 pathogen present in their baseline specimen culture.See Post-text Data Listing 2.6.1.Of the 256 cases with a CRE isolate, 222(86.4%)cases had K. pneumoniae present in the baseline specimen culture; 2(0.8%)had K. oxytoca; 18(7.0%)had Enterobacter cloacae; 4(1.6%)had E. aerogenes; and the remainder had other Enterobacteriaceae present.Of all 76 cases of cUTI/AP, 59(77.6%)cases had K. pneumoniae present in the baseline specimen culture; 5(6.6%)cases had E. coli; 4(5.3%)cases had E. cloacae; and 2(2.6%)cases had E. aerogenes present.Of all 21 cases of HABP, 18(85.7%)cases had K. pneumoniae present in the baseline specimen culture; 3(14.3%)cases had E. cloacae; and 1(4.8%)case had E. aerogenes present.No cases of HABP were associated with E. coli.Of all 20 cases of VABP, 18(90.0%)cases had K. pneumoniae present in the baseline specimen culture; and 3(15%)cases had E. cloacae present.No cases of VABP were associated with E. aerogenes or E. coli.See Post-text Data Listing 2.6.1 for a summary of pathogens for All Cases.