The incidence of esophageal cancer

食管癌的发病率在世界范围内呈上升趋势，肿瘤标志物的发展将<br>有助于食管癌的早期诊断和改善预后。随着检测技术的发展，肿瘤标志物作为辅助诊断手段将越来越重要。RPN2 <br>在多种癌症中发挥肿瘤的遗传功能[15]。Honma等。报道说，RPN2沉默<br>在多西他赛的存在下可在体内外诱导乳腺癌细胞凋亡[16]。藤田等。报道说<br>，RPN2的下调显着抑制了致瘤性并使肿瘤对顺铂治疗敏感，这延长了<br>非小细胞肺癌小鼠的存活率[17]。Hong等。证明siRNA-RPN2可以通过AKT / PI3K信号传导显着抑制人鼻咽癌细胞的侵袭和迁移<br>[12]。仓重等。有报道称，RPN2在食管鳞状细胞<br>癌内窥镜活检标本中的表达可能预示了基于多西他赛的化疗反应[14]。<br>尚不清楚RNP2在食管癌进展中的作用和机制。在我们的研究中，我们首次报告<br>与正常组织相比，RPN2 表达在食管癌组织中显着增加。另外，RNP2<br>与正常的食道上皮细胞<br>系相比，在食道癌细胞系中的表达也显着升高。这些结果表明RPN2可以在食道癌中发挥致癌作用。

The incidence of esophageal cancer is increasing all over the world, and the development of tumor markers will be<br>helpful for early diagnosis and improved prognosis of esophageal cancer. With the development of detection technology, tumor markers will become more and more important as auxiliary diagnostic means. RPN2 exerts tumor<br>genetic functions in many kinds of cancer [15]. Honma et al. reported that RPN2 silencing induced apoptosis of<br>breast cancer cells in the presence of docetaxel, in vitro and in vivo [16]. Fujita et al. reported that down-regulation<br>of RPN2 significantly inhibited tumorigenicity and sensitized the tumors to cisplatin treatment, which lengthened<br>the survival of mice with non-small-cell lung cancer [17]. Hong et al. demonstrated that siRNA-RPN2 could dramatically suppress the invasion and migration of human nasopharyngeal carcinoma cells through AKT/PI3K signaling<br>[12]. Kurashige et al. reported that RPN2 expression in endoscopic biopsy specimens of oesophageal squamous cell<br>carcinoma might predict response to docetaxel-based chemotherapy [14]. The role and mechanism of RNP2 in the<br>progression of esophageal cancer was not investigated clearly. In our study, we report for the first time that RPN2<br>expression is significantly increased in the esophageal cancer tissue compared with normal tissue. In addition, RNP2<br>expression is also elevated notably in esophageal cancer cell lines compared with normal esophageal epithelial cell<br>lines. These results indicate that RPN2 could exert an oncogenic role in esophageal cancer.

食管癌的发病率在世界范围内呈上升趋势，肿瘤标志物的研究也将随之发展<br>有助于食管癌的早期诊断和改善预后。随着检测技术的发展，肿瘤标志物作为辅助诊断手段将变得越来越重要。RPN2引发肿瘤<br>多种癌症的遗传功能[15]。Honma等人。报道了RPN2沉默诱导细胞凋亡<br>多西紫杉醇存在下的乳腺癌细胞，体外和体内[16]。Fujita等人。报道说<br>RPN2显著抑制肿瘤的发生，并使肿瘤对顺铂治疗敏感，使肿瘤延长<br>非小细胞肺癌小鼠的存活率[17]。Hong等人。证明siRNA-RPN2可通过AKT/PI3K信号通路显著抑制鼻咽癌细胞的侵袭和迁移<br>[12] 一。Kurashige等人。报道了RPN2在食管鳞状细胞内镜活检标本中的表达<br>癌细胞可能预测多西紫杉醇化疗的疗效[14]。RNP2在大鼠脑缺血再灌注损伤中的作用及机制<br>食管癌的进展没有明确的调查。在我们的研究中，我们首次报道了RPN2<br>与正常组织相比，食管癌组织中的表达显著增加。此外，RNP2<br>与正常食管上皮细胞相比，食管癌细胞系的表达也显著升高<br>线。这些结果表明，RPN2可能在食管癌中发挥致癌作用。<br>