IBD-associated taxa were also highl

IBD-associated taxa were also highly correlated with metabotype in a study of inactive pediatric IBD. In the same study, healthy first-degree relatives displayed a similar microbiome and metabotype as relatives with inactive disease. Both CD and UC gut microbiomes exhibit general decreases in taxonomic diversity relative to healthy gut microbiomes, along with Phylum-level decreases in Firmicutes and increases in Proteobacteria. In CD specifically, proportions of the Clostridia family are altered: the Roseburia and Faecalibacterium genera of the Lachnospiracae and Ruminococcaceae families are decreased, whereas Ruminococcus gnavus increases.