In the past, colorectal PC was trad

In the past, colorectal PC was traditionally regarded as a terminal disease treated only in a palliative setting through supportive care, palliative surgery, and chemotherapy, achieving survival rates of a few months. The widespread use of newer chemotherapeutic agents such as oxaliplatin and irinotecan in addition to 5-FU, as well as novel targeted agents like bevacizumab and cetuximab, has led to an improvement in survival rates in advanced stage CRC. In parallel, there has been an increase of surgical resections and ablative procedures being performed for stage IV disease, and curative intent hepatic and pulmonary metastatectomy are now routinely carried out. However, PM generally used to be considered inoperable and surgery for PC of CRC was reserved only for palliation or for treatment of complications such as gastrointestinal obstruction, bleeding, or perforation and requirement for repeated ascitic aspiration