总之，本研究开发了一种同时具有良好的生物相容性、可调控平滑肌细胞的增值

总之，本研究开发了一种同时具有良好的生物相容性、可调控平滑肌细胞的增值、促进内皮化、抑制炎症反应预防血栓形成的作用且能性能相对稳定的药物控释涂层；探讨了基于多酚介导的“三明治”模型涂层改性全降解血管支架及人工小口径血管治疗动脉粥样硬化的应用；为基于多酚介导的 “三明治”模型涂层改性心血管材料大规模推广应用提供理论基础。<br><br>关键词：多酚化合物，层层自组装（LBL），支架介入治疗，冠状动脉旁路移植术，人工小血管，表没食子儿茶素没食子酸酯，聚己内酯（PCL），

In conclusion, a drug controlled release coating with good biocompatibility, regulating the proliferation of smooth muscle cells, promoting endothelialization, inhibiting inflammatory reaction and preventing thrombosis was developed; The application of polyphenol mediated "sandwich" model coating modified fully degradable vascular stent and artificial small caliber vessel in the treatment of atherosclerosis was discussed; It provides a theoretical basis for the large-scale popularization and application of polyphenol mediated "sandwich" model coating modified cardiovascular materials.<br>Keywords: polyphenol compounds, layer by layer self-assembly (LBL), stent interventional therapy, coronary artery bypass grafting, artificial small vessels, epigallocatechin gallate, polycaprolactone (PCL),

In a word, this study developed a drug controlled release coating with good biocompatibility, regulating the proliferation of smooth muscle cells, promoting endothelialization, inhibiting inflammation and preventing thrombosis, and relatively stable performance. This paper discusses the application of "sandwich" model coating modified fully degradable vascular stent and artificial small-diameter blood vessel in the treatment of atherosclerosis. It provides a theoretical basis for the large-scale popularization and application of "sandwich" model coating modified cardiovascular materials based on polyphenols. Key words: polyphenol compounds, layer-by-layer self-assembly (LBL), stent intervention, coronary artery bypass grafting, artificial small blood vessels, epigallocatechin gallate, polycaprolactone (PCL),