5. How to dissolve compounds in DMSO?DMSO is used frequently in cell banking applications as a cryoprotectant because it prevents intracellular and extracellular crystals from forming in cells during the freezing process. For most cryopreservation applications, DMSO is used at the concentration of 10%, and is usually combined with saline or serum albumin.Compounds can be dissolved easily in DMSO. However, DMSO might be cytotoxic to cells, even though DMSO increases cell permeability. High concentrations of DMSO should never be used for cell culture. Most cell lines can tolerate 0.5% DMSO, and some cells can tolerate up to 1%. However, primary cell cultures are far more sensitive. Therefore, if you are using primary cells a dose-re- sponse curve (viability), it should be performed with DMSO concentrations