These grades correlate with one- and two-year patient survival.One-year patient survival(%)Two-year patient survival(%)A:well-compensated diseaseB:significant functional compromiseC:decompensated diseaseAppendix 7 NYHA Classification - The Stages of Heart FailureAppendix 8 Sharma scaleSeverity of symptom using the Sharma scale as follows:Subject symptom scores(range 0 to 11):sum of these sub-scores(0=no symptoms, 11=worst possible symptoms).Subject age(years)will be derived as(screening date - birth date)/365.25 and truncated to the largest integer that is less than or equal to the calculated result.BMI(kg/m2)will be derived as Weight(kg)/[Height(cm)/100]2 and rounded to the nearest decimal.If the start and end dates of the adverse event are identical then “