Further, faecal calprotectin levels alone were able to distinguish patients with pouchitis from those without pouchitis (AUC 0.63).By contrast, a microbiome species model (with or without faecal calprotectin level as an additional predictor) achieved an AUC of 0.78, confirming that microbial profiling had a superior diagnostic performance to faecal calprotectin levels alone in the identification of pouchitis.