细胞表面的力的变化似乎像开关一样，可以直接触发细胞内蛋白质和信号通路的

Changes in forces on the cell surface appear to act like switches that can directly trigger changes in proteins and signaling pathways within the cell. This has important implications for probing immune mechanisms. Liu Wanli's team and Xiong Chunyang's team jointly discussed the detailed characteristics and related mechanisms of the traction force in the immune synapse during the activation of B cells. By building a traction force microscopy platform combined with a confocal live cell imaging system. The team found that B cells generate a centripetal pull of 10-20 nanometers within 5 minutes from quiescence to activation. This traction force is distributed around the cell periphery and can last for 30 minutes. In vitro genetic screening and rescue experiments revealed the roles of some signaling molecules in the proximal membrane BCR pathway for the generation and maintenance of traction. This is a great contribution to the study of B cell immune activation.

The change of cell surface force seems to be like a switch, which can directly trigger the changes of intracellular proteins and signal pathways. This is of great significance to explore the immune mechanism. Liu Wanli's team and Xiong Chunyang's team jointly discussed the detailed characteristics and related mechanisms of immune synaptic traction in the process of B cell activation. By establishing a traction microscope platform, combined with confocal live cell imaging system. The team found that B cells produce 10-20 nanometers of centripetal traction within 5 minutes from rest to activation. This traction force is distributed around the cell and can last for 30 minutes. In vitro genetic screening and rescue experiments revealed the role of some signal molecules in the proximal membrane BCR pathway in the generation and maintenance of traction. This is a great contribution to the study of B cell immune activation.

The change of cell surface force seems to be like a switch, which can directly trigger the change of intracellular protein and signal pathway. This is of great significance to explore the immune mechanism. Liu Wanli's team and Xiong Chunyang's team jointly discussed the detailed characteristics and related mechanisms of intrasynaptic traction during B cell activation. By establishing a traction microscope platform and combining with confocal living cell imaging system. The team found that B cells produced 10-20 nm centripetal traction within 5 minutes from rest to activation. This traction force is distributed around the cell and can last for 30 minutes. In vitro genetic screening and rescue experiments revealed the role of some signal molecules in proximal membrane BCR pathway in the generation and maintenance of traction. This is a great contribution to the study of B cell immune activation.