金属锰是重要的矿产资源，来源和应用广泛，但它不是百利无一害的，人体长期

Manganese metal is an important mineral resource with a wide range of sources and applications, but it is not harmless. Long-term inhalation of manganese to the human body can cause occupational manganese poisoning. The main target of its toxicological effects is the nervous system, which can cause damage to the nervous system. Studies have shown that curcumin can activate the silencing regulator of microglia information (SIRT1) and interfere with the occurrence of its inflammation. Therefore, this review uses curcumin to interfere with the neuroinflammatory response of manganese to microglia to understand its mechanism of action. The study of manganese on the neurotoxicity mechanism provides a theoretical basis, and also provides a certain theoretical knowledge for the prevention and treatment of manganese on the nervous system damage.

金属锰是重要的矿产资源，来源和应用广泛，但它不是百利无一害的，人体长期吸入锰会造成职业性锰中毒。其毒理作用的主要靶点是神经系统，会造成神经系统的损伤。研究表明姜黄素可激活小胶质细胞信息沉默调节剂（SIRT1），干扰其炎症的发生，因此，本综述通过姜黄素干扰锰对神经小胶质细胞神经炎性反应，了解其作用机理，为研究锰对神经毒理机制提供理论基础，也为锰对神经系统损伤的预防和治疗提供一定的理论知识。<br>

Manganese is an important mineral resource with wide sources and applications, but it is not harmless. Long-term inhalation of manganese by human body will cause occupational manganese poisoning. The main target of its toxicological action is the nervous system, which will cause damage to the nervous system. Studies have shown that curcumin can activate SIRT1 and interfere with the occurrence of inflammation. Therefore, through curcumin interfering with neuroinflammatory reaction of manganese to microglia, the mechanism of action is understood, which provides a theoretical basis for studying the neurotoxic mechanism of manganese, and also provides some theoretical knowledge for the prevention and treatment of nerve system injury caused by manganese.