Autoimmune disorders occur because of the impairment of immune system tolerance to autoantigens. Disturbances of the efferocytosis process, as the result of an impaired clearance of apoptotic cells because of abnormal find-me or eat-me signals, defects in surface receptors of phagocytes,bridging molecules or their signaling pathways, may result in autoimmune disorders in humans, including systemic lupus erythematosus and rheumatoid arthritis