In conclusion, this study demonstrates that heated intraperitoneal oxaliplatin is a feasible intra-operative treatment. The pharmacokinetic study indicates a dose-related exposure andefficient intratumoural penetration. The clinical study showsthat 460 mg/m2 oxaliplatin in 2 l/m2 of instillate over 30–40min at 43°C is well tolerated compared with previous resultswith IPCH.