Objective: To explore the effectiveness of evidence-based nursing in preventing incision infection in patients after cardiac surgery, in order to provide a strong objective basis for targeted nursing intervention plans for clinical cardiac surgery patients. Method: A total of 100 patients admitted to the cardiology department of our hospital from February 2023 to August 2023 were randomly divided into a control group and an observation group, with 50 patients in each group. All patients were scheduled for surgical treatment, and different nursing interventions were taken according to their grouping. The control group received routine care, while the observation group received evidence-based care. The postoperative wound healing of the two groups was observed and evaluated, and clinical indicators of the two groups were statistically analyzed, Detect changes in blood cell indicators such as hemoglobin (Hb), white blood cell (WBC), and neutrophil (N%) levels before and after nursing intervention in two groups. Use Kolcaba's General Comfort Questionnaire (GCQ) to evaluate the physical and mental well-being of both groups before, 3 days after, and 7 days after nursing intervention. Result: The incision healing rate in the observation group was higher than that in the control group (P<0.05); The observation group had shorter surgical time, incision recovery time, antibiotic application time, and hospital stay compared to the control group (P<0.05); Before nursing intervention, there was no significant difference in Hb, WBC, and N% levels between the two groups (P>0.05). After nursing intervention, the WBC and N% levels in the observation group were higher than those in the control group, while Hb levels were lower than those in the control group (P<0.05); Before nursing intervention, there was no significant difference in GCQ scores between the two groups (P>0.05). On the 3rd and 7th days after nursing intervention, the GCQ scores of the observation group were higher than those of the control group (P<0.05). Conclusion: The application of evidence-based nursing to patients after cardiac surgery has a significant effect on preventing incision infection. Nursing intervention can not only avoid postoperative incision infection, but also promote incision healing, which is of great significance for consolidating surgical treatment effectiveness, preventing postoperative inflammatory reactions, and improving physical and mental comfort. It is worth vigorously promoting
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