Since glass containers are usually used to store solutions and conduct reactions, they are generally considered to be inert, and few people have studied their effects on reactions. Recently, Professor R. Graham Cooks of Purdue University in the United States and others proposed the use of glass to accelerate the Katritzky reaction, and found that the silanol group on the glass surface can promote the deprotonation of the Katritzky reaction, thereby accelerating the progress of the reaction. In addition, the author also studied the effect of glass on the Katritzky reaction kinetics based on the electrospray mass spectrometry characterization of the reaction process, and proved the principle of the interface (gas/liquid interface and solid/liquid interface) to accelerate the reaction.
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