1,6-烯炔类化合物的环化反应是构筑环状结构行之有效的合成方法，并且一

The cyclization reaction of 1,6-enyne compounds is an effective method for building cyclic structures, and has always been the focus of attention of chemists. Among them, the asymmetric reductive cyclization of 1,6-enyne has attracted the attention of chemists and achieved certain results in the search for different transition metals, chiral ligands and hydrogen sources. Traditional synthesis methods generally use hydrogen, silane, ethanol, and borane as the hydrogen source. Although, the response has achieved certain results. However, it is still the pursuit of organic chemists to find a hydrogen source that is easy to obtain, clean, carbon-free, and environmentally friendly. <br>This subject successfully realized the asymmetric reductive cyclization reaction of 1,6-enyne with water as the hydrogen source by rhodium, established an effective catalytic system, and obtained the reductive cyclization product of 1,6-enyne. The highest rate can reach XX%, and the ee value can reach XX%. In future research, we will continue to investigate the steric hindrance and electronic effects of the reaction, and strive to obtain a catalytic system with a wide range of applications, high yield and high enantioselectivity.

The cyclic reaction of 1,6-enefin is an effective synthesis method to construct ring structure, and has always been the focus of chemists. In this, the asymmetric reduction cyclification reaction of 1,6-ene has been paid attention to by chemists and achieved some results in the search for different transition metals, hand-held liges and hydrogen sources. Traditional synthesis methods generally use hydrogen, silane, ethanol and boronane as hydrogen sources. Although, the response has yielded some results. However, finding an easy-to-access, clean, carbon-free, green source of hydrogen is still what organic chemists seek.<br>This topic successfully realized the asymmetric reduction ring reaction of water-based hydrogen source of 1,6-eneene, established an effective catalytic system, and obtained 1,6-eneene reduction ringing product, yield up to XX, ee value up to XX. In future studies, we will continue to examine the spatial and electronic effects of the reaction in order to obtain a catalytic system with a wide range of applications, high yields and high pairing selectivity.

Cyclization of 1,6-enynes is an effective synthetic method to construct cyclic structure, and has been the focus of chemists. Among them, the asymmetric reductive cyclization of 1,6-enynes has attracted the attention of chemists in the search for different transition metals, chiral ligands and hydrogen sources. Traditional synthesis methods generally use hydrogen, silane, ethanol and borane as hydrogen sources. Although, the reaction has achieved some results. However, it is still the pursuit of organic chemists to find easy to obtain, clean, carbon free, green hydrogen sources.<br>In this project, rhodium catalyzed asymmetric reductive cyclization of 1,6-enynes with water as hydrogen source was successfully realized. An effective catalytic system was established, and the reductive cyclization products of 1,6-enynes were obtained. The highest yield and EE value were XX% and XX%, respectively. In the future, we will continue to investigate the steric hindrance effect and electronic effect of the reaction, and strive to obtain a catalytic system with wide application, high yield and high enantioselectivity.<br>