These findings only involve a single genomic target, and it is unclear whether the impact of maternal care is limited to a single gene or whether it leads to global long-term reprogramming of the adult hippocampal transcriptome. In addition, it is still unclear whether the expression of maternal regulatory genes will be affected by the same pharmacological operations that will reverse the effect of maternal care on GR expression. To solve these problems, we used microarray analysis to study the effect of maternal care on overall gene expression in the hippocampal transcriptome of adult offspring.
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