significant associations between TL

significant associations between TLR6 and atopy15. There are no other convincing earlier reportsabout correlation between TLR6 and atopy. TLR6 forms heterodimers with another major TLR´s involved in allergicresponses, such as TLR1 and TLR2, and is also expressed on mast cells, which plays animportant role in allergy28. The interaction between different genotypes and TLR´s probablymean that one single SNP can influence the function of the whole TLR2 heterodimer and thus,more studies are needed to evaluate the association between the haplotype of TLR2 heterodimerand atopy.Despite many studies, asthma pathogenesis in childhood is not yet completelyunderstood. Early viral respiratory infections, especially rhinovirus, are known to be associatedwith increased asthma risk2, 4, 29 Infantile immune system can be directed towards Th2-orientedatopic responses by early viral infection, or some individuals can already be predisposed toasthma due to impaired lung function and the post-viral immune responses may be only reactiveto infection 3. TLR polymorphism causes impaired immune responses due to lowered recognitionof pathogens which have been linked to asthma and atopy 30. In our present study, children withwild homozygous genotypes in all three investigated TLR SNP´s were significantly less likely todevelop asthma after viral bronchiolitis in infancy. This finding provides preliminary evidencethat alterations in TLR genotypes, at least in the TLR2 subfamily, may increase the later asthmasusceptibility due to lowered capability of innate immunity to defend against severe early-liferespiratory infection.Daley et al (2012) studied the combined effect of early respiratory virus infectionand TLR SNP´s on asthma and atopy risks among 7-year-old children 15. Interestingly, atopicasthma risk was associated with TLR1 rs4543123 SNP and RSV infection during the first year of