[Abstract] Objective To study the effect of pharmaceutical intervention on rational clinical application of antibiotics. Methods 60 patients with antibiotic treatment were randomly divided into control group and observation group, 30 cases in each group. The patients in the observation group were given pharmaceutical intervention, while the patients in the control group were given routine medication management. The irrational drug use, adverse reactions and satisfaction scores of the two groups were compared. Results the irrational rate of clinical medication in the observation group was 0, which was significantly lower than 13.33% of the control group (P<BR>