3. Results and discussionEven though SYA has been proved to have potential hepatoprotective activities, its application in vivo is questionable because of the poor solubility and absorption in its pure form. It is noteworthy that, INH is a highly soluble drug, which is much more soluble than SYA [24]. The great solubility advantage of INH in comparison with SYA may be beneficial to enhance the solubility, and furthermore to improve SYA’s pharmacokinetic properties. Since the formation of cocrystal of INH with SYA will usually balance the physical and chemical properties of the two compounds, and further optimize the pharmacokinetic synergy. However, cocrystallizing INH and SYA into the same lattice is also particularly difficult due to the huge differences in their solubilities. To overcome this problem, a wide screening of different methods such as liquid-assisted grinding, vapor diffusion, slurrying crystal, and evaporation were undertaken. Finally, the cocrystallization of
3. Results and discussion<br>Even though SYA has been proved to have potential hepatoprotective activities, its application in <br>vivo is questionable because of the poor solubility and absorption in its pure form. It is noteworthy <br>that, INH is a highly soluble drug, which is much more soluble than SYA [24]. The great solubility <br>advantage of INH in comparison with SYA may be beneficial to enhance the solubility, and <br>furthermore to improve SYA’s pharmacokinetic properties. Since the formation of cocrystal of INH <br>with SYA will usually balance the physical and chemical properties of the two compounds, and <br>further optimize the pharmacokinetic synergy. However, cocrystallizing INH and SYA into the <br>same lattice is also particularly difficult due to the huge differences in their solubilities. To <br>overcome this problem, a wide screening of different methods such as liquid-assisted grinding, <br>vapor diffusion, slurrying crystal, and evaporation were undertaken. Finally, the cocrystallization of
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