Currently, the exact pathomechanism

Currently, the exact pathomechanisms which lead to hypertrophic scarring are not yet completely understood. Various studies, like from Butzelaar et al. [1] or Sarrazy et al. [3]investigating the background of pathological scarring, observed several differences in the genesis of HS compared to the normal wound healing process. To summarize study results briefly, hypertrophic scarring is related to an prolonged inflammatory phase followed by pathological modifications of wound healing process such as hypercellularity, augmented neovascularization and excessive collagen production.Specific hypertrophic scar fibroblasts found in HS tissue show a greater expression of TGF-β1, causing an overproduction of collagen. Furthermore, an imbalance of collagen production and collagenases (like matrix metalloproteinases, MMP) also occurs, leading to a dysfunctional remodeling of granulation tissue and resultant hypertrophic scarring[1–4]. The complexity of the wound healing process may explain the current This article is protected by copyright. All rights reserved. 5variety of treatment methods for hypertrophic scarring. Silicone products are an early treatment modality which have been used since 1980 [2]. Silicone products may influence hypertrophic scarring by enabling constant hydration of the scar tissue as a consequence of the applied silicone membrane. Another treatment method is the application of mechanical pressure to the scar surface via pressure garments to decrease blood and oxygen flow into the scar tissue, which may reduce cellularproliferation and prevent excessive scarring[4–6]. Other studies recommend the use ofmore invasive methods such as intralesional injections of corticosteroids,

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结果 (简体中文) 1: [复制]

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目前，导致肥厚性瘢痕形成的确切病理机制尚未完全了解。各种研究，例如Butzelaar等。[1]或Sarrazy等。[3] 调查病理性瘢痕形成的背景，观察到与正常伤口愈合过程相比，HS的起源存在一些差异。简而言之，肥厚性瘢痕形成与炎性期延长有关，随后是伤口愈合过程的病理改变，例如细胞过多，新生血管增多和胶原蛋白生成过多.HS组织中发现的特定肥厚性瘢痕成纤维细胞显示TGF-β1的更高表达，导致胶原蛋白过剩。此外，还会发生胶原蛋白生成和胶原酶（如基质金属蛋白酶，MMP）的失衡，导致肉芽组织功能失调，并导致肥厚性瘢痕形成[1-4]。伤口愈合过程的复杂性可以解释当前 本文受版权保护。版权所有。5肥厚性瘢痕的各种治疗方法。自1980年以来，有机硅产品已成为一种早期治疗方法[2]。有机硅产品可能会由于所施加的有机硅膜而导致疤痕组织持续水合，从而影响肥大性瘢痕形成。另一种治疗方法是通过压力服对疤痕表面施加机械压力，以减少血液和氧气流入疤痕组织，这可以减少细胞 增殖并防止过多的疤痕形成[4-6]。其他研究建议使用 更具侵入性的方法，例如病灶内注射皮质类固醇，

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结果 (简体中文) 2:[复制]

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Currently, the exact pathomechanisms which lead to hypertrophic scarring are not yet completely understood. Various studies, like from Butzelaar et al. [1] or Sarrazy et al. [3] investigating the background of pathological scarring, observed several differences in the genesis of HS compared to the normal wound healing process. To summarize study results briefly, hypertrophic scarring is related to an prolonged inflammatory phase followed by pathological modifications of wound healing process such as hypercellularity, augmented neovascularization and excessive collagen production.Specific hypertrophic scar fibroblasts found in HS tissue show a greater expression of TGF-β1, causing an overproduction of collagen. Furthermore, an imbalance of collagen production and collagenases (like matrix metalloproteinases, MMP) also occurs, leading to a dysfunctional remodeling of granulation tissue and resultant hypertrophic scarring[1–4]. The complexity of the wound healing process may explain the current This article is protected by copyright. All rights reserved. 5variety of treatment methods for hypertrophic scarring. Silicone products are an early treatment modality which have been used since 1980 [2]. Silicone products may influence hypertrophic scarring by enabling constant hydration of the scar tissue as a consequence of the applied silicone membrane. Another treatment method is the application of mechanical pressure to the scar surface via pressure garments to decrease blood and oxygen flow into the scar tissue, which may reduce cellular proliferation and prevent excessive scarring[4–6]. Other studies recommend the use of more invasive methods such as intralesional injections of corticosteroids,

正在翻译中..

结果 (简体中文) 3:[复制]

复制成功！

目前，导致增生性瘢痕形成的确切病理机制尚不完全清楚。各种研究，如Butzelaar等人。[1] 或者Sarrazy等人。[三] 研究病理性瘢痕形成的背景，观察HS的发生与正常创面愈合过程的差异。简单总结一下研究结果，增生性瘢痕形成与炎症期延长以及伤口愈合过程的病理改变有关，如细胞增生，新生血管增强与过量胶原具体生产增生性瘢痕成纤维细胞在HS组织中表达TGF-β1，导致胶原过多。此外，胶原生成和胶原酶（如基质金属蛋白酶，MMP）的不平衡也会发生，导致肉芽组织的功能失调重塑和增生性瘢痕形成[1-4]。伤口愈合过程的复杂性可以解释 这篇文章受版权保护。保留所有权利。增生性瘢痕的各种治疗方法。硅酮产品是一种早期的治疗方法，自1980年以来就开始使用[2]。硅酮产品可通过使应用硅酮膜后的疤痕组织持续水合而影响增生性疤痕。另一种治疗方法是通过压力衣对疤痕表面施加机械压力，以减少进入疤痕组织的血液和氧气流量，从而减少细胞 增殖和防止过度疤痕[4-6]。其他研究建议使用 更具侵入性的方法，如皮质类固醇的损伤内注射，

正在翻译中..

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