代紫阳等[ ]研究发现，葛根素能够上调PI3K、p-Akt蛋白表达，下

代紫阳等[ ]研究发现，葛根素能够上调PI3K、p-Akt蛋白表达，下调GSK-3β蛋白表达并增强其磷酸失活水平，通过增强PI3K/Akt/GSK-3β信号转导过程，增加肝细胞内糖原含量，改善Hep G2细胞的胰岛素抵抗状态。匙羹藤总皂苷可以通过增强PI3K、AKT磷酸化和糖原合成水平，降低PEPCK和G6Pase活性表达，通过多环节、多靶点激活脂肪组织PI3K/AKT信号通路，改善T2DM大鼠IR状态[ ]。

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结果 (英语) 1: [复制]

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Generation Ziyang, [] found that puerarin can be regulated PI3K, p-Akt protein, down-regulated expression of GSK-3β and enhance its phosphorylation inactivation level, by enhancing the PI3K / Akt / GSK-3β signal transduction, increases in liver intracellular glycogen content, improve insulin resistance in Hep G2 cells. Gymnema sylvestre total saponins can be enhanced PI3K, AKT phosphorylation and glycogen synthesis levels, decreased expression of PEPCK and G6Pase activity by multi-link, multi-target adipose tissue activate PI3K / AKT signaling pathway, to improve the IR state T2DM rats [] .

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结果 (英语) 2:[复制]

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The study found that gegensin was able to raise PI3K, p-Akt protein expression, reduce GSK-3 beta protein expression and enhance its phosphoric acid inactivation level, and increase the glycogen content in liver cells by enhancing the PI3K/Akt/GSK-3 beta signal transduction process, and improve the insulin resistance of Hep G2 cells. Spoon toe total saponin can improve the IR state of T2DM rats by enhancing PI3K, AKT phosphorylation and glycogen synthesis levels, reducing PEPCK and G6Pase activity expression, and activating the adipose PI3K/AKT signaling pathway through multiple links and multiple targets.

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结果 (英语) 3:[复制]

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Dai Ziyang et al [] found that puerarin can up regulate the expression of PI3K and p-Akt protein, down regulate the expression of GSK-3 β protein and enhance its phosphoric acid inactivation level. Through enhancing the PI3K / Akt / GSK-3 β signal transduction process, it can increase the glycogen content in hepatocytes and improve the insulin resistance of HepG2 cells. The total saponins of Gymnema gymnoides can reduce the expression of PEPCK and G6Pase activity by enhancing the level of PI3K, Akt phosphorylation and glycogen synthesis, activate the PI3K / Akt signal pathway in adipose tissue through multiple links and targets, and improve the IR state of T2DM rats.

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