New techniques, such as organoid technology, create great opportunities for future HIPEC research. Organoids are three-dimensional stem cell cultures that self-organize intoex vivo ‘mini-organs’. Organoids generated from colorectalcarcinomas can be used to test several cytotoxic agents,concentrations, durations, temperatures and frequencies, to optimize current intraperitoneal chemotherapy. The firststudy to use this approach showed that oxaliplatin was the most efficient cytotoxic agent in patients with PC ofcolorectal cancer origin