Three of the top five genes are neutrophil chemokines (CXCL9, CXCL10, and CXCL13) or neutrophil associated (S100A8), and the most up-regulated genes in the responders (SLC26A2, CDHR1) have known roles in UC or inflammation.SLC26A2 regulates the transport of sulfate and oxalate across cell membranes (Karniski 2010).