An endoscopic system comprising: a computer processing system; a high-definition display having a display area of at least 12 inches diagonally in electrical communication with the computer processing system for receiving and displaying endoscopic images; and a handheld portion comprising: a multiple-use handle portion having mechanical and electrical couplers for accepting a single-use portion and a cable in electrical communication between said multiple-use handle portion and the computer processing system; and a single-use portion that includes an elongated, cannula having a camera module mounted on a distal end and having mechanical and electrical couplers on a proximal end configured to releasably couple with said couplers of the multiple-use handle portion when the handle portion and the single-use portion are assembled into said handheld portion, the cannula and camera module being configured to rotate around a central longitudinal axis of the cannula relative to the multiple-use handle portion; a first sensor configured to detect rotational movement or rotational position of the cannula and camera module about the central axis relative to the multiple-use portion; and a second sensor configured to detect rotational movement or rotational position of the multiple-use handle portion about an axis parallel to the central axis relative to the display monitor.