In Vitro Permeation Test (IVPT) StudiesWe found similar permeation profiles for 2 acyclovir productsusing human epidermal membranes & dermatomed skin;dermal membranes are very permeable!• Supports SC being main underlying barrier• Suggests that either epidermal membranes or dermatomed skin could beused in acyclovir IVPT studies• Skin barrier integrity is an important control component to get right