轻度脑外伤（mTBI）是引发认知障碍的重要原因，mTBI后认知障碍的相

轻度脑外伤（mTBI）是引发认知障碍的重要原因，mTBI后认知障碍的相关机制尚未阐明。目前认知障碍缺少影像客观诊断依据，造成临床对认知障碍警惕不足。申请人前期采用磁共振研究mTBI动物模型，发现mTBI主要包括：血脑屏障、脑血流、脑功能、大脑网络连接、脑皮层体积和厚度、脑白质和灰质结构的异常。模型慢性期（7个月）伴有认知障碍，经磁共振弥散峰度成像检查，发现脑皮质、皮质下核团平均弥散峰度值异常升高并与认知障碍高度相关。申请人推测mTBI后脑组织修复重建过程与认知障碍的发生有内在的逻辑联系。本课题拟用mTBI动物模型和临床病例，从行为学、量表、生物标记物、磁共振、PET-CT、病理和电镜检查，对mTBI后认知障碍的发生发展进行连续动态观察、揭示mTBI修复重建关联认知障碍的作用，阐明mTBI发生认知障碍的机制，明确mTBI后早期诊断认知障碍的客观影像学特征，形成影像诊断认知障碍的临床实用价值。

Mild brain injury (MTBI) is an important cause of cognitive impairment. The related mechanism of cognitive impairment after MTBI has not been clarified. At present, there is a lack of objective diagnostic basis for cognitive impairment, resulting in insufficient clinical vigilance for cognitive impairment. In the earlier stage, the applicant used magnetic resonance to study the MTBI animal model and found that MTBI mainly includes: blood-brain barrier, cerebral blood flow, brain function, brain network connection, volume and thickness of cerebral cortex, abnormalities of white matter and gray matter structure. The chronic phase (7 months) of the model was accompanied by cognitive impairment. Magnetic resonance diffusion kurtosis imaging showed that the average diffusion kurtosis of cerebral cortex and subcortical nucleus increased abnormally, which was highly correlated with cognitive impairment. The applicant speculates that there is an internal logical connection between the process of brain tissue repair and reconstruction after MTBI and the occurrence of cognitive impairment. This subject intends to use MTBI animal model and clinical cases to continuously and dynamically observe the occurrence and development of cognitive impairment after MTBI from the aspects of behavior, scale, biomarkers, magnetic resonance, PET-CT, pathology and electron microscopy, reveal the role of MTBI repair and reconstruction related to cognitive impairment, and clarify the mechanism of cognitive impairment after MTBI, To clarify the objective imaging characteristics of early diagnosis of cognitive impairment after MTBI, so as to form the clinical practical value of image diagnosis of cognitive impairment.

Mild traumatic brain injury (mTBI) is an important cause of cognitive impairment, and the related mechanism of cognitive impairment after mTBI has not been clarified. At present, there is a lack of objective diagnostic evidence of cognitive impairment, which leads to insufficient clinical vigilance against cognitive impairment. In the early stage of the applicant, the animal model of mTBI was studied by magnetic resonance, and it was found that mTBI mainly includes: blood-brain barrier, cerebral blood flow, brain function, brain network connection, volume and thickness of cerebral cortex, abnormalities of white matter and gray matter structure. In the chronic stage (7 months), the model was accompanied by cognitive impairment. Through magnetic resonance diffusion kurtosis imaging, it was found that the average diffusion kurtosis of cerebral cortex and subcortical nuclei was abnormally increased and highly correlated with cognitive impairment. The applicant speculated that the process of brain tissue repair and reconstruction after mTBI was logically related to the occurrence of cognitive impairment. This topic intends to use mTBI animal model and clinical cases to continuously and dynamically observe the occurrence and development of cognitive impairment after mTBI from the aspects of behavior, scale, biomarkers, magnetic resonance, PET-CT, pathology and electron microscopy, reveal the role of mTBI in repairing and reconstructing related cognitive impairment, clarify the mechanism of cognitive impairment after mTBI, clarify the objective imaging features of early diagnosis of cognitive impairment after mTBI, and form the clinical practical value of imaging diagnosis of cognitive impairment.