A variety of efflux pump systems are found in Enterobacteriaceae, among which the AcrAB-Tolc efflux pump system is the most common and widespread. It often mediates the resistance of Escherichia coli and Klebsiella pneumoniae to a variety of antibacterial drugs, especially β-lactam antibacterial drugs, and is considered to be the <br>main resistance in CRE that does not produce carbapenemase. mechanism
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