这表明灯盏花素对ＣＹＰ３Ａ４的抑制作用可能通过ＰＸＲ途径调节；虽然有研

This indicates that the inhibitory effect of Breviscapine on CYP3A4 may be regulated by the PXR pathway; although some studies have shown that the effects of some compounds on CYP2C19 will also be affected by the PXR pathway, and the research results show that Breviscapine has inconsistent expressions of PXR and CYP2C19. It is preliminarily judged that the effect of breviscapine on CYP2C19 may not be through the PXR pathway, and CAR is the key regulatory factor of CYP2C19. Whether breviscapine affects the expression of CYP2C19 through the CAR pathway, the exact mechanism of action needs further discussion.

This suggests that the inhibitory effect of calpentine on CYP3A4 may be regulated by the PXR pathway, although studies have shown that the effects of some compounds on CYP2C19 are also affected by the PXR pathway, and the results show that the inhibitory flowers on PXR and CYP2C1 9 expression is inconsistent, can be initially judged the effect of lamp alcanin on CYP2C19 may not be through the PXR way, and CAR as the key control factor of CYP2C19, whether the lampal alcanin is affected by THE CAR pathway The expression of CYP2C19, its exact mechanism of action needs further exploration

This indicates that the inhibitory effect of breviscapine on CYP3A4 may be regulated by PXR pathway; although some studies have shown that the effects of breviscapine on CYP2C19 are also affected by PXR pathway, the results show that breviscapine has different expression of PXR and CYP2C19, which can be preliminarily judged that breviscapine has no effect on CYP2C19 The effect of breviscapine on CYP2C19 may not be mediated by PXR pathway. As a key regulator of CYP2C19, whether breviscapine affects the expression of CYP2C19 through car pathway needs to be further explored