In this paper, the dynamic responses of train-bridge system under one-way and two-way high-speed train passing are studied. The 3D finite element modeling is used and the bridge and train are modeled considering their details. The created model is validated by the results of the dynamic field test. To study the effect of train speed, different train passing scenarios are analyzed, including one-way passing, two-way passing in different directions at same speeds, and two-way passing in different directions at different speeds. The results show that the locations of maximum acceleration are different in one-way and two-way passing modes, and the maximum values in two-way passing mode are higher than those in one-way passing mode, while the maximum accelerations in both modes are almost identical. The displacement and acceleration values in different scenarios show peaks at speeds of 260 and 120 km/h, due to the proximity of the natural frequencies of the bridge and loading frequencies of the train at these speeds.