there was a significant increase in

there was a significant increase in the activity of the resting statein the following brain regions of SCD patients: inferior parietallobule, right superior temporal gyrus, right inferior temporalgyrus, fusiform gyrus, and right posterior lobe of the cerebellum.This confirms the existence of compensatory mechanisms inspontaneous activities of SCD patients at the resting state.Another study suggested that patients with APOEε4 presentedboth increased and decreased functional connectivity as reflectedin default mode network (DMN), which is correlated with clinicalcognitive performances based on the regions of interest (ROI)-based functional connectivity analyses and voxel-based analyses(56). Thus, altered functional connectivity may be an early signof cognitive decline. A resting-state fMRI study mainly revealedthat SCD individuals had reduced correlations between centralityfrequency (i.e., across the entire time window, the proportion oftime that the hub appeared was defined as centrality frequency)of the anterior cortical regions and cognitive performance,compared with normal controls (NCs). In contrast, correlationsbetween centrality frequency of the posterior cortical regions andcognitive performance were stronger in SCD participants than