Examples of the beneficial effects

Examples of the beneficial effects of cyclodextrins as functional excipients on APIs are highlightedby Conceição et al. [14], which include the increased solubility of carbamazepine by means ofcomplexation with HP-β-CD. The effect of complexation of carbamazepine with HP-β-CD is furtherillustrated by a study conducted by Kou et al. [17]. A complex of HP-β-CD with carbamazepinewas prepared in the presence of 0.1% hydroxypropyl methyl cellulose (HPMC). The formed complexhad increased the solubility of carbamazepine up to 95 times when compared to the drug alone.Furthermore, the complexation of carbamazepine with HP-β-CD rendered a 1.5-fold increase inthe bioavailability of carbamazepine in beagle dogs when compared with an immediate-releasecommercially available carbamazepine tablet. The HP-β-CD-containing formulation rendered amaximum plasma concentration (Cmax) of 4951.04 ± 1585.21 ng/mL and area under the curve (AUC0–∞)of 8597.85 ± 2786.18 ng·h/mL in comparison to a Cmax of 3577.99 ± 1444.90 ng/mL and AUC0–∞of 6000.65 ± 2227.61 ng·h/mL for the commercially available formulation. The improvement inbioavailability was attributed to an increase in dissolution rate of the HP-β-cyclodextrin complexcontaining formulation [17]