The electrospun PCL vascular grafts

The electrospun PCL vascular grafts were modified with a polyphenol embedding sandwiched layer-by-layer coating (PEI/EGCG-DEX/HEP)30. The in vitro heparin/dexamethasone release assays demonstrated that the(PEI/EGCG-DEX/HEP)30 performed desirable loading amount and sustained release properties without serious initial burst due to the embedded EGCG, which endowed the coating with a bundant intermolecular interactions between coating components (e.g.,π-πstacking, weak intermolecular cross-linking and enriched hydrogen bonding).Along with this,the in vitro hemocompatibility evaluations confirmed the excellent and prolonged anticoagulant ability of modified PCL vascular grafts,which even retained excellent anticoagulant properties after 14- day immersion, and the results were also proved by ex vivo arteriovenous shunt assay.Meanwhile,the(PEI/EGCG-DEX/HEP)30 could inhibit the inflammation reaction by inhibiting macrophages activation. The mild inflammation reaction of modified materials after subcutaneous implantation further confirmed the anti-inflammatory properties of (PEI/EGCG-DEX/HEP)30. This facile and in expensive sandwiched layer-by-layer coating (PEI/EGCG-DEX/HEP)30 exhibited great potential in improving long-term patency of artificial vascular grafts. Inaddition, it could also have broad application potential in surface modification of other blood-contacting materials.