Neurons in our nervous system, use electrical impulses to transmit Information throughout our bodies. This process is mediated by membrane proteins called voltage gated ion channels. Voltage gated ion channels open and close in reaction to changes in membrane voltage or membrane potential. A cell membrane potential is generated by concentration gradient of positively charged sodium and potassium ions across the membrane. When a neuron is at rest, its ion channels are closed. And the overall concentrations of ions and proteins create a higher potential on the outside and a lower potential on the inside. This state is referred to as resting potential. The membrane is said to be polarized to transmit a signal.