优化强脉冲光治疗睑缘炎相关性角结膜病变的临床研究 吕学锋 沈锦霞 陈雅

Clinical study of optimized intense pulsed light in treatment of blepharitis-related corneal conjunctival lesions <br>Lv Xuefeng Shen Jinxia Chen Yaqiong <br>Wuhan Aige Eye Hospital 430019 <br>[Abstract] Objective To explore the effect of optimized intense pulsed light (OPT) in the treatment of blepharitis-related corneal conjunctival lesions (BKC) . Methods In this study, 54 patients diagnosed with BKV were treated with OPT combined with hormone therapy. Before treatment, 2wk, 4wk and 8wk after treatment, subjective symptoms, eyelid margin morphology, meibomian gland secretion traits, and corneal conjunctival lesions were included. And other aspects of clinical evaluation. Results After OPT treatment in 54 patients with BKC, all indexes were significantly lower than the previous one. The OSDI score decreased from (65.14 ± 18.56) points before treatment to (38.77 ± 15.13) points after treatment 2wk and (29.15 ± 17.42) after 4 weeks treatment Points, after 8wk (13.22 ± 11.57) points (P <0.05), the eyelid margin score decreased from before treatment (3.46 ± 0.71) to 2wk (1.87 ± 1.13) points, after 4wk (1.24 ± 0.81) points and 8wK (0.64 ± 0.56) points (P <0.05), the meibomian gland secretion trait decreased from (13.66 ± 1.82) points before treatment to (9.75 ± 2.32) points after 2wk, (7.55 ± 2.46) points after 4wk and 8wk The last (5.19 ± 2.51) points (P <0.05). After 2 weeks of treatment, 38 patients had corneal stroma infiltration and absorption, most of the ulcers healed, and neovascularization began to degenerate. 17 patients were cured, 21 were effective, and the total effective rate was 70.4%. After 4 weeks of treatment, all patients had no hyperemia of the eyelid margin, conjunctival hyperemia disappeared, corneal infiltration and absorption, ulcer healing, scar formation, and neovascularization subsided. The cure rate reached 100%. No complications such as skin lesions occurred in the course of all patients. Conclusion OPT can be used as an effective physical therapy for BKC. <br>Keywords: blepharitis-related corneal conjunctival disease; optimized intense pulsed light; corticosteroids

Clinical study of optimizing the treatment of blepharic symbiotis-related conjunctiva diseases<br> Lu Xuefeng Shen Jinxia Chen Yaqiong<br> Wuhan Ag Eye Hospital 430019<br>Objective To explore the efficacy of optimizing the treatment of blepharitis-related corneal conjunctivities (BKC) by strong pulsed light (OPT). Methods In this study, 54 patients diagnosed as BKV were treated with OPT-combined hormone therapy, and clinical evaluation of the characteristics of subjective symptoms, blepular morphology, eyelid gland secretion traits and the range of corneal lesions were carried out before and after treatment. Results After OPT treatment in 54 BKC patients, the indicators were significantly lower than the previous time, and the OSDI score decreased from pre-treatment (65.14 to 18.56) to 2wk after treatment (38.77 x 15.13) and 4wk (29.1) After 5 to 17.42) and 8wk (13.22 x 11.57) (P 0.05), the margin score was reduced from pre-treatment (3.46 x 0.71) to 2wk after (1.87 x 1.13), After 4wk (1.24 x 0.81) and 8wK (0.64 x 0.56) (P 0.05), the eyelid gland secretion traits by the pre-treatment (13.66 x 1.82) ) after a score of 2wk (9.75 x 2.32) after , after 4 wk ( 7.55 x 2.46) and 8 wk after (5.19 x 2.51) cents (P 0.05). After treatment of 2wk, 38 patients in the corneal matrix immersion absorption, ulcers mostly healed, new blood vessels began to recede, 17 cases of cure, 21 cases effective, the total efficiency of 70.4%. After treatment of 4wk, all patients have no congestion on the lid, conjunctiva congestion disappears, corneal leaching absorption, ulcer healing, scar formation, new blood vessels subside, cure rate of 100%. All patients did not experience complications such as skin damage during the procedure. Conclusion OPT can be used as an effective physiotherapy method for BKC.<br>Keywords: blepharitis-associated corneal conjunctivities; optimized strong pulsed light; corticosteroid hormones

Clinical study on the treatment of blepharitis related keratoconjunctival diseases with optimized intense pulse light<br>LV Xuefeng, Shen Jinxia, Chen Yaqiong<br>Wuhan egger eye hospital 430019<br>[Abstract] Objective To investigate the effect of optimized intense pulsed light (OPT) on blepharitis associated keratoconjunctival disease (BKC). Methods 54 patients with BKV were treated with opt combined with hormone. Before and after the treatment, the clinical evaluation of subjective symptoms, morphology of meibomian margin, secretion of meibomian gland and the range of keratoconjunctival lesions were carried out at 2wk, 4wk and 8wk. result 56) points The secretions of meibomian gland decreased from 13.66 ± 1.82 to 9.75 ± 2.32, 7.55 ± 2.46 and 5.19 ± 2.51 (P < 0.05). After 2 weeks of treatment, corneal stroma infiltration and absorption, ulcer healing and neovascularization began in 38 cases, 17 cases were cured, 21 cases were effective, the total effective rate was 70.4%. After 4 weeks of treatment, there was no hyperemia at the eyelid margin, conjunctival hyperemia disappeared, corneal infiltration and absorption, ulcer healing, scar formation, neovascularization disappeared, and the cure rate was 100%. No complications such as skin lesions occurred in all patients. Conclusion opt can be used as an effective physical therapy for BKC.<br>Key words: blepharitis related keratoconjunctivitis; optimized intense pulsed light; corticosteroid hormone<br>