Flupyradifurone, a novel butenolide insecticide25 applied at recommended label rates and investigated in this study, was shown to effffectively protect tomato plants from TYLCV infections vectored by B. tabaci MED. Under high virus inoculum pressure approximately 85% of the flflupyradifurone-treated plants were not found to be infected by the virus, whereas thiamethoxam – a neonicotinoid insecticide – largely failed to keep TYLCV infestation levels under economic damage thresholds. Molecular TYLCV PCR-driven diagnostic tests and visual assessment of infection symptoms were in agreement, thus confifirming the validity of the fifindings. However, recent studies under lower virus pressure using a B. tabaci MEAM1 strain revealed that foliar applications of thiamethoxam show prompt but short-lasting protection (