Some publications describe the use of a standard perfusate volume of 2 l m2with a fixed dose of 460 mg m2. In this case, all patients are treated with a fixed concentration of 230 mg l1oxaliplatin in the perfusate at the beginning of the HIPEC procedure. Using perfusate volumes above 2 l m2, alongwith a fixed dose per m2, might negatively influence efficacybecause tumour exposure will be decreased. However, the useof fixed volumes of 2 l m2 can cause inadequate tissue contact time in patients with a relative large abdominal cavity