围术期神经认知紊乱（Perioperative Neurocognit

Perioperative neurocognitive disorder (Perioperative Neurocognitive Disorders, PND) in elderly patients perioperative one of the most common diseases, the current consensus at home and abroad believe PND is in "a third year low" state, that is the high incidence of early signs of awareness low, low rate of accurate diagnosis and hospitalization coverage before, during hospitalization and after discharge integration of families in more aspects of the whole course of the monitoring system configuration is low. Construction of screening for early warning indicators PND, PND develop standardized monitoring system beneficial to the whole course of treatment PND window forward. May be embedded in the wearable device based on the identification and early rehabilitation application cerebral infarction and patients with Huntington's disease and other neurological and our previous study demonstrated α2- adrenergic receptor agonists useful cerebral protective effect, the present study was to triaxial accelerometer sensor wearable device to capture surgery in elderly patients with clinical data and daily life gait, gait recognition PND build predictive models and remote health data platform through deep learning, the development of standardized integrated whole course of PND monitoring system, real-time evaluation α2- adrenoceptor agonist dexmedetomidine given a protective effect on brain PND, that window forward PND prevention and treatment to provide a stable and reliable early warning system and provide new drug clinical application of evidence-based evidence.

Perioperative Neurocognitive Disorders (Perieoperative Neurocognitive Disorders, PND) is one of the most common diseases in the perioperative period of elderly patients, and there is a consensus at home and abroad that PND is in a "high three low" state, i.e. high incidence, low early signs of awareness, The diagnostic accuracy is low and the integrated whole disease monitoring system that covers pre-hospital, during hospitalization, post-discharge and family links is low. The construction of PND early screening early warning index and the development of PND standardized whole disease monitoring system are beneficial to the pND treatment window. Based on the application of wearable devices in the early identification and rehabilitation of patients with neurological disorders such as cerebral infarction and Huntington's disease, and our previous studies confirming that alpha 2-adrenaline receptor agonists are beneficial to brain protection, this study aims to collect gait data for the clinical and daily life of elderly surgical patients by embedding wearable devices with three-axis accelerometer sensors. Through deep learning to establish gait recognition PND prediction model and remote health data platform, the development of standardized integrated whole disease PND monitoring system, real-time evaluation of alpha 2-adrenaline receptor agonist right metomidin on PND brain protection role, It provides a stable and reliable early warning system and clinical application of drugs to provide new evidence-based evidence for the forward ingress of PND prevention and control window.

围手术期神经认知障碍PND）是老年患者围术期最常见的疾病之一，目前国内外的共识认为PND处于“一高三低”状态，即发病率高、早期体征知晓率低、诊断准确率低以及覆盖住院前、住院期间、出院后和家庭多个环节的一体化全病程监测体系配置低。构建PND早期筛查预警指标，开发PND规范化全病程监测系统有益于PND治疗窗口前移。基于穿戴设备在脑梗和亨廷顿等神经系统疾病患者早期识别和康复中的应用以及我们前期研究证实α2-肾上腺素受体激动剂有益于脑保护作用，本研究拟通过三轴加速度计传感器嵌入可穿戴设备采集老年手术患者的临床和日常生活步态数据，通过深度学习建立步态识别PND预测模型和远程健康数据平台，开发规范化的一体化全病程PND监测系统，实时评价α2-肾上腺素受体激动剂右美托咪定对PND的脑保护作用，以为PND防治窗口前移提供稳定可靠的预警体系和药物临床应用提供新的循证证据。<br>