目前，有关齐墩果酸的药物有齐墩果酸片、二至丸、复方女贞子胶囊、贞扶正口

目前，有关齐墩果酸的药物有齐墩果酸片、二至丸、复方女贞子胶囊、贞扶正口服液等，但因为齐墩果酸具有强疏水性，其片剂生物利用度低，颜耀东等实验用环糊精对齐墩果酸进行包合，结果可使齐果酸的溶解度提高12倍，票积溶出速率增大6倍，且齐果酸与β环糊精分子间除物理作用外，无化学键生成，制备过程中齐果酸亦未发生分解反应，因此齐墩果酸的生物利用度大大提高，另外，蒋朝晖等根据前体药物的理论，对齐墩果酸进行了结构修饰，在Cs-OH与二元酸形成单酯，再转化为二钠盐，使其成为可溶于水的二钠盐前体药物，现已合成齐墩果酸琥珀酸单酯二钠、齐墩果酸马来酸单酯二钠、齐墩果酸环已烷邻二甲酸单酯二钠、齐墩果酸邻苯二甲酸单酯二钠等，且经初步药理实验结果表明，这些二钠盐对实验性肝损伤的保护作用比齐墩果酸均有不同程度的提高，而且无齐墩果酸在大剂量时会加重肝脏损伤和副作用 另外，也可以从改变齐墩果酸药物剂型来提高齐墩果酸药物的生物利用度，增加疗效。

目前，有关齐墩果酸的药物有齐墩果酸片、二至丸、复方女贞子胶囊、贞扶正口服液等，但因为齐墩果酸具有强疏水性，其片剂生物利用度低，颜耀东等实验用环糊精对齐墩果酸进行包合，结果可使齐果酸的溶解度提高12倍，票积溶出速率增大6倍 ，且齐果酸与β环糊精分子间除物理作用外，无化学键生成，制备过程中齐果酸亦未发生分解反应，因此齐墩果酸的生物利用度大大提高，另外，蒋朝晖等根据前体药物的理论，对齐墩果酸进行了结构修饰，在Cs-OH与二元酸形成单酯， 再转化为二钠盐，使其成为可溶于水的二钠盐前体药物，现已合成齐墩果酸琥珀酸单酯二钠、齐墩果酸马来酸单酯二钠、齐墩果酸环已烷邻二甲酸单酯二钠、齐墩果酸邻苯二甲酸单酯二钠等，且经初步药理实验结果表明， 这些二钠盐对实验性肝损伤的保护作用比齐墩果酸均有不同程度的提高，而且无齐墩果酸在大剂量时会加重肝脏损伤和副作用 另外，也可以从改变齐墩果酸药物剂型来提高齐墩果酸药物的生物利用度，增加疗效。

At present, there are oleanolic acid tablets, Erzhi Pills, compound Ligustrum lucidum capsules, zhenfuzheng oral liquid, etc. but because oleanolic acid has strong hydrophobicity, its tablet bioavailability is low, Yan Yaodong and other experimental cyclodextrins were used to package oleanolic acid, the results can increase the solubility of oleanolic acid by 12 times, the dissolution rate of ticket product by 6 times, and the dissolution rate of oleanolic acid and β - cyclo In addition to physical interaction, there is no chemical bond formation between dextrin molecules, and there is no decomposition reaction of oleanolic acid in the preparation process. Therefore, the bioavailability of oleanolic acid is greatly improved. In addition, according to the theory of precursor drugs, Jiang Zhaohui et al. Modified the structure of oleanolic acid, formed a monoester between CS oh and binary acid, and then converted to disodium salt, making it a disodium salt soluble in water In recent years, oleanolic acid monoester disodium succinate, oleanolic acid maleic acid monoester disodium, oleanolic acid cyclohexane phthalate monoester disodium, oleanolic acid phthalic acid monoester disodium and so on have been synthesized. The preliminary pharmacological experiment results show that the protective effect of these disodium salts on experimental liver injury is higher than that of oleanolic acid In addition, it can also improve the bioavailability of oleanolic acid drugs by changing the dosage form of oleanolic acid drugs.<br>