Similarly, Kim et al.reported that BHS could suppress invasion of breast cancer cells through downregulating another chemokine CXCL12 as well as its binding receptor CXCR4 (CXC chemokine receptor 4) (Kim and Park, 2014). Additionally, it was reported that BHS also exhibited theselective immunosuppressive effects on T-cell and B-cell activation in vitro (Ma et al., 2004), suggesting that BHS may remodel the tumor immune microenvironment through modulating lymphocytes. Considering the complexity of the tumor immune microenvironment, a better illumination about the modulatory effects of BHS on other types of chemokines and immune cells is still needed to study in the future.