目前，传统抗生素的耐药性日益加重，使得寻找新型的抗菌药物是解决耐药菌问

At present, the resistance of traditional antibiotics is increasing day by day, making finding new antibacterial drugs the fundamental way to solve the problem of resistant bacteria. Antimicrobial peptides are a new type of natural peptide molecule, which has a wide range of inhibitory effects on bacteria, etc. It has the irreplaceable advantages of general antibiotics, but its activity in the human body will be affected and satisfactory treatment results cannot be achieved. Therefore, based on the structure of natural antimicrobial peptides, we can design and synthesize new antimicrobial peptide mimics to better meet the needs. This thesis is based on the structural characteristics of the hydrophilic positive charge and lipophilic side chain shared by antimicrobial peptides. Honokiol, which has an antibacterial effect and lipophilic side chain, is used as raw material. After alkylation and hydrolysis, the hydroxyl group is The introduction of cationic groups of different lengths-amino groups to construct the amphiphilic structural characteristics of the compound, forming a new type of antimicrobial peptide mimic. The synthesis of the compounds in this paper is simple and convenient, and the yield is high. The compound used the micro broth dilution method to determine its minimum inhibitory concentration. The results showed that the compound showed better antibacterial activity than the control compound ciprofloxacin against a variety of gram-positive and negative bacteria, proving its superior antibacterial activity . Although the number of antimicrobial peptide mimics that can be used in clinical treatment is still relatively limited, with the continuous development of science and technology in this field, in the future, more antimicrobial peptide mimics will definitely be applied to clinical treatment and become antimicrobial An indispensable part of medicine.

At present, the resistance of traditional antibiotics is increasing day by day, so that the search for new antimicrobial drugs is the fundamental way to solve the problem of drug-resistant bacteria. Antibacterial peptide is a new type of natural peptide molecule, which has a wide inhibitory effect on bacteria and so on, and has the irreplaceable advantages of general antibiotics, but its activity in the human body will be affected and can not achieve satisfactory therapeutic results. Therefore, based on the natural antibacterial peptide structure, the design and synthesis of new antimicrobial peptide simulators to make it more in line with the needs. Based on the structural characteristics of hydrophoviral positive charge and lipid-pro-lipid side chain common to antimicrobial peptides, this paper introduces cation group-amino of different lengths on hydroxyl by hydrocarbon reaction and hydrolysis reaction, and constructs the structural characteristics of compound biffin, forming a new type of antibacterial peptide analog. The synthesis of compounds in this paper is simple and convenient, and the yield is high at the same time. The compound used trace broth dilution to determine its minimum antibacterial concentration, and the results showed that the compound showed better antibacterial activity than the controlled compound cycloproxacin for a variety of Gram-positive bacteria and negative bacteria, and proved its superior antibacterial activity. Although the number of antimicrobial peptide simulators that can be applied to clinical treatment is still relatively limited, with the continuous development of science and technology in this field, more antimicrobial peptide simulators will be applied to clinical treatment in the future and become an indispensable part of antimicrobial drugs. ...

At present, the resistance of traditional antibiotics is becoming more and more serious, so it is the fundamental way to find new antibiotics to solve the problem of drug-resistant bacteria. Antimicrobial peptides are a new class of natural peptide molecules, which have a wide range of inhibitory effects on bacteria, and have irreplaceable advantages. However, the activity of antimicrobial peptides in human body will be affected, which can not achieve satisfactory therapeutic results. Therefore, based on the structure of natural antimicrobial peptides, we designed and synthesized new antibacterial peptide mimics to meet the needs. Based on the structural characteristics of hydrophilic positive charge and lipophilic side chain of antimicrobial peptides, magnolol with antibacterial and lipophilic side chain was used as raw material to construct amphiphilic structural characteristics by alkylation and hydrolysis of honokiol, which had antibacterial and lipophilic side chains, to construct the amphiphilic structural characteristics of the compounds and form a new antibacterial peptide mimic. The synthesis of the compounds in this paper is simple and convenient, and the yield is high. The minimal inhibitory concentration (MIC) of the compound was determined by broth microdilution method. The results showed that the compound showed better antibacterial activity than ciprofloxacin against a variety of gram-positive and negative bacteria. Although the number of antimicrobial peptide mimics that can be used in clinical treatment is still relatively limited, with the continuous development of science and technology in this field, in the future, more antimicrobial peptide mimics will be used in clinical treatment and become an indispensable part of antibacterial drugs.<br>