supplements for human consumption, and also have industrial or environmental potential. With respect to human health, some studies show positive effects of phenolics from grape bagasse, such as decreased oxidation of low-density lipoproteins, reduction of cardiovascular disease and cancer, and antimicrobial, antioxidant, and anti-inflammatory properties, so they are considered as chemopreventive agents. The need to find natural sources of these compounds lies not only in the efficient use of this kind of byproduct, but also in having feasible and profitable methodologies that allow minimization of the environmental impact through the use of green extraction techniques. More studies are needed in order to develop suitable methods for the recovery of grape bagasse phenolics. Advances in knowledge about their biological activities are also important in order to allow effective and safe use of these compounds.