The recommended dose of 240 mg QD with food is safe. To reduce the incidence of diarrhea, which was the main DLT, we recommended prophylactic use of loperamide with neratinib during the first 1-2 months of treatment.
The recommended dose of 240 mg QD with food is safe. To reduce the incidence of diarrhea, which was the main DLT, we recommended prophylactic use of loperamide with neratinib during the first 1-2 months of treatment.