The use of contrast agents in the skin with X-ray tomography. Using the Carl Zeiss Versa-510system unstained skin may be visualised. However, contrast is low and the differentiation of structureswithin the skin is difficult. The use of PTA or I2KI contrasting agents improves the differentiation obtainedbetween structures in the skin. PTA provides the best contrast when looking at structures within theskin, however, due to its molecular size, its rate of staining is slow and full penetration of the tissue is notachieved, even after many hours