The long-term course of chronic sinusitis indicates that the relationship between the host and the environment is complex, and the effect of treatment based on the cause of the disease is not ideal. At present, the focus of CRS has shifted from exploring individual complex pathogenic factors to tissue inflammatory effects caused by pathogenic factors. There are many susceptibility factors for refractory sinusitis. At present, biological treatment is developing rapidly, and there are a variety of biological treatment options, all of which can significantly reduce the need for surgery and improve symptoms.
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