Cyclophosphamide is the alkylating agent that interferes with DNA
replication. The results of the French Pulmonary Hypertension Network showed that some chemotherapeutics could be associated
with pulmonary venous occlusive disease.22The most responsible
for pulmonary embolism were cyclophosphamide (43%), mitomycin
C (24.3%), and cisplatin (21.6%).22Interestingly, the majority of