Compressors are the main excitation source of vibration and noise in camper air-conditioning systems, which directly affects the NVH characteristics in campers. The vibration and noise reduction for camper comfort improvement can be implemented by the optimization method. This paper presents vibration and noise improvement in camper by systematically optimizing the vibration isolation performance of air-conditioning compressor. To analyze the compressor vibration characteristics, operational vibration tests under different conditions and modal identification are implemented. Based on the analysis results, a genetic algorithm is used to optimize the stiffness of the compressor vibration isolation element by the energy decoupling method (EDM). The stiffness, natural frequencies, and energy decoupling rate (EDR) of the compressor vibration isolation system (CVIS) are compared between preoptimization and postoptimization. The stiffness and strength characteristics of the optimized isolation system are verified by the finite element method. Operational vibration and noise tests of a camper are performed to validate the optimization effect. The improvement of camper comfort demonstrates that the proposed optimization procedure of CVIS is effective.