Ideal Lightsheet for Live Cell ImagingLightsheet imaging offers fast fluorescence imaging with decreased light dose at the sample plane compared to confocal imaging. Conventional selective plane illumination microscopy (SPIM) methods use a Gaussian beam where light sheet thickness is proportional to light sheet length, leading to a beam that is typically too short or thick for ideal sub-cellular imaging. The innovative Lattice LightSheet combines the flexibility of a Gaussian light sheet with the thin optical sectioning of a Bessel beam to achieve the best optical sectioning of any light sheet microscope