Despite of the studies done for tracking and vibration control of ball-screw drive mentioned previously, it is needed to consider the dynamic variation .A single-input single-output (SISO) [7] is first considered for the stiffness variation of the ball-screw system and considers its modeling and controller is selected accordingly, the dynamic variations were identified and designed a gainscheduled controller. When considering the plant variations occurs during the controller design of MIMO model as that of gain-Scheduled approach for SISO model, Adams and Apkarian developed an advanced form of gain-scheduled controller [9].Based on the above study, analyzed a robust gain-scheduling controller [10] for proper tracking of ballscrew drive system, but in this work, they did not considers any cutting force disturbances on the work piece table of ball-screw system to avoid excitation. A two-loop tracking control [11] is synthesized and applied a motion controller and the disturbance observer for both tracking and vibration control. In this work, the controller chosen for the proper tracking to be the fuzzy logic controller [14],[15],[16]and[17] for proving the effectiveness of the proposed controller,the simulation result is compared with the conventional PID controller.