CLP or Sham-operated mice were trained for Morris water maze task from the 4th day to 7th day after surgery.The mice were place on the platform for a total of 10 seconds and were then removed from the pool. In the subsequent training session, the mice were individually placed into eachof the 4 quadrants and were allowed to search the platform for a period of 60 seconds. If the mice were unable to reach the platform within 60 seconds, they would be placed on the platform for an additional 10 seconds. The escape latency, distance of swimming, and time spent in the target quadrant were recorded for each training process.